The series scored the Rose d'Or for Best Reality and Factual Entertainment program at the ceremony in Berlin.

It beat out other high-profile nominees including ITV's This Time Next Year, the original UK version of Nine's hit hosted by Karl Stefanovic.

Fellow Aussie nominee, Nine's Here Come The Habibs, lost out in the Best Comedy category to Amazon Prime/BBC's critical fave Fleabag by British star Phoebe Waller-Bridge.

You Can't Ask That, which began as an iView-only series for the ABC, features marginalised groups addressing the awkward misconceptions and rude questions they face in day-to-day life.

The second season, which finished its run on ABC's main channel in May, included episodes focusing on blind people, refugees, homeless people, gambling addicts, and the children of same-sex couples.

It's been a word-of-mouth success for the national broadcaster, earning critical raves for sparking "civilised, intelligent conversation" around difficult and oft-ignored issues.

ABC's Director of Television David Anderson called the win "tremendous", while the show's producer Aaron Smith thanked its guests for sharing their stories.

"You Can't Ask That 100 per cent relies on the graciousness and bravery of the participants who are kind enough to lend their voice. We wish to say thank you to those who put their trust in us," he said in a statement following the win.

The Rose d'Or Awards have been handed out annually by the European Broadcasting Union since 1961.

Australian shows have had some success in recent years, with SBS's Go Back To Where You Came From taking out the Factual Entertainment category in 2012 and ABC's Gruen Sweat winning Best Entertainment program in 2013.

Other winners this year included British game show Bigheads and Norwegian drama Nobel. Angela Lansbury was given a Lifetime Achievement Award, while James Corden earned the ceremony's first Entertainer of the Year prize.