The Globe Inn, established in 1847 and located just a 45-minute drive from Canberra and 15 minutes from the Murrumbateman wineries, is being sold by owners Greg Miller and David Small.

They say they're ready for a new challenge after making the tree change from Sydney to Yass to purchase the Georgian guesthouse in 2012.

"We've put a lot of love into the place," Mr Small said. "It was already established as accommodation when we moved here, but it was low-key."

Mr Miller and Mr Small have restored the hotel's original veranda and kitchen and refurbished the four queen bedrooms, which all have individual en suites.

The hotel sits on a 1200-square metre block and also has a Mediterranean garden room with a stone floor, wood fire and bath for the romantics.

There is an adjoining two bedrooms, one bathroom apartment where Mr Miller and Mr Small live with their dog, Patti. This allows couple to cater to their guests and have some separation from the business in their home lives.

The Globe, a beacon welcoming visitors into the centre of the town, has played host to many meetings, balls and theatrical entertainment over the years.

It was also once the booking office for 'The Telegraph Line of American Covered Coaches' between Yass and Young.

"It's always been used as some sort of accommodation," Mr Miller said. "It was a hotel up until 1880, then it became a boarding house and then flats."

"A lot of people in town have a strong tie to the property, they either lived here or knew children that lived here and came to play when they were younger," he said.

The Globe also has a guest lounge, dining room and old ballroom that is used for functions. The property, despite being an old building, is warmed by ducted heating.

Yass Valley Property is managing the sale and agency principal Andrew Curlewis commended the work Mr Miller and Mr Small have put into the hotel.

"These guys have really built the business up," Mr Curlewis said.

Mr Miller and Mr Small were at the forefront of a shift in the town when they purchased The Globe seven years ago.

"We felt something was happening in the area," Mr Small said.

"Clementine Restaurant and Yazzbar weren't here when we moved in and most of the wineries didn't have cellar doors. Now, Yass has become a real destination," he said.

Clementine Restaurant and Yazzbar offer boutique dining and drinking options for visitors and locals alike

"We call it the magic triangle," Mr Miller said. "A lot of people start at Yazzbar, have dinner at Clementine and then stay at The Globe."

"It's been positive and rewarding to be a part of what's happened in Yass," Mr Small said.

"We've no regrets with what we've done," Mr Miller said.

The hotel has had some famous guests under Mr Miller and Mr Small's management. Although, Mr Miller said, "a lot prefer not to be named."

Mr Miller and Mr Small would like the new owner to continue to run The Globe just as they have.

"It's set-up for someone to continue to run it and we've got a lot of advanced bookings already," Mr Small said.

"We try to offer something not available anywhere else in town," he said.

"It's quite a personal service," Mr Miller said.

They're not sure where they're off to, but hopefully, they'll stick around in town for a little while longer.

Yass Valley Property is receiving expressions of interest. Their contact number is 02 6226 6331.